![]() These SLC genes, although most of them act as transporters, have different expression patterns in auditory organs and distinct function in hearing. Besides, another 13 SLC members were reported to be associated with hearing loss or involved in auditory organ development. Among these genes, five of them belong to the SLC family. More than 200 hearing loss genes, including the syndromic and the nonsyndromic hearing loss genes, were identified in the last decades ( ). ![]() The causes of hearing loss vary, from congenital to acquired impairments, but the defects of genes account for the majority. Hearing is one of the most important sensory functions, and hearing loss would cause great inconvenience to the daily life of deaf people. In this review, we summarize all SLCs related to hearing systematically ( Figure 1B) in order to explore the expression patterns and possible functions. It has been reported that some of the SLCs are associated with hearing loss, including auditory organ development and hearing dysfunction. This summary could help us understand the auditory physiology and the mechanisms of hearing loss and further guide future studies of deafness gene identification. In this review, we summarize SLC family genes related with hearing dysfunction to reveal the vital roles of these transporters in auditory function. It has been found that mutations in some SLC members are associated with hearing loss. SLCs also play important roles in hearing. They play crucial roles in transporting many important molecules, such as ions and some metabolites, across the membrane, maintaining cellular homeostasis. Solute carriers (SLCs) are important transmembrane transporters with members organized into 65 families.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |